Neosporin is composed of which three antibiotics?

• A. Bacitracin, Polymyxin B, and Neomycin
• B. Bacitracin and Polymyxin B
• C. Amoxicillin, Clavulanic acid, and Neomycin
• D. Penicillin G and Streptomycin

Answer: (A)

Neosporin is a topical triple-antibiotic ointment designed to cover a broad range of skin bacteria by combining three different antibiotics. The three components are bacitracin, polymyxin B, and neomycin. Each antibiotic contributes a different mechanism—bacitracin inhibits cell wall synthesis, polymyxin B disrupts the bacterial cell membrane, and neomycin (an aminoglycoside) inhibits protein synthesis by binding the 30S ribosomal subunit—yielding broad-spectrum activity against common skin pathogens. The other options omit one or more of these components or list antibiotics not used in Neosporin, so they don’t match the actual formulation.