Which NSAID is most associated with Stevens-Johnson syndrome?

• A. Aspirin
• B. Indomethacin
• C. Celecoxib
• D. Naproxen sodium

Answer: (C)

Stevens-Johnson syndrome is a rare but serious drug reaction that starts with fever and flu-like symptoms, then rapidly progresses to a painful, spreading rash with mucous membrane involvement. Among NSAIDs, the signal for this severe skin reaction is strongest with celecoxib in many pharmacology references and case reports, making it the option most associated with SJS in this set. This doesn’t mean other NSAIDs can’t cause SJS, but the documented association tends to be most notable for celecoxib here. If a patient develops a new, severe rash or mucosal lesions after starting an NSAID, stop the drug immediately and seek urgent medical evaluation.