Which of the following is NOT an SSRI?

• A. Fluoxetine
• B. Escitalopram
• C. Venlafaxine
• D. Citalopram

Answer: (C)

This question tests your ability to distinguish between antidepressants by their reuptake targets. SSRIs selectively block the reuptake of serotonin, increasing serotonin availability in the synapse. Fluoxetine, escitalopram, and citalopram all fit this category. Venlafaxine, however, is not an SSRI—it’s an SNRI. It inhibits the reuptake of both serotonin and norepinephrine, and its norepinephrine effect becomes more pronounced at higher doses. That broader action places it outside the SSRI class, even though it can share similar uses with SSRIs.