Which of the following is NOT an opiate analgesic?

• A. Tramadol
• B. Meperidine
• C. Oxycodone
• D. Cyclobenzaprine

Answer: (D)

The key idea is distinguishing opioid (opiate) analgesics from drugs that are not opioids. Opiate analgesics relieve pain by acting on opioid receptors in the central nervous system. Tramadol, meperidine, and oxycodone are all opioids: tramadol is a weak mu receptor agonist with additional monoamine reuptake inhibition, while meperidine and oxycodone are classic opioid receptor agonists used for pain relief.

Cyclobenzaprine, however, is a central-acting muscle relaxant used to treat muscle spasm. It does not provide analgesia through opioid receptors and is not classified as an opioid analgesic, so it is not an opiate analgesic.