Which of the following is a first-generation H1 blocker?

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Multiple Choice

Which of the following is a first-generation H1 blocker?

Explanation:
First-generation H1 blockers cross the blood–brain barrier readily, leading to sedation and often anticholinergic side effects. Chlorpheniramine is a classic example of this generation, which is why it’s the correct choice. The other drugs—cetirizine, loratadine, and fexofenadine—are second-generation H1 blockers designed to minimize CNS penetration, so they are typically non-sedating or only mildly sedating and have fewer anticholinergic effects.

First-generation H1 blockers cross the blood–brain barrier readily, leading to sedation and often anticholinergic side effects. Chlorpheniramine is a classic example of this generation, which is why it’s the correct choice. The other drugs—cetirizine, loratadine, and fexofenadine—are second-generation H1 blockers designed to minimize CNS penetration, so they are typically non-sedating or only mildly sedating and have fewer anticholinergic effects.

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