Which of the following is NOT typically associated with isotretinoin use?

• A. Blepharoconjunctivitis
• B. Mydriasis
• C. Dry eyes
• D. PTC

Answer: (B)

Isotretinoin commonly dries and irritates the eye surfaces because it reduces tear production and alters the glands that keep the eyelids lubricated. This leads to dry eyes and eyelid-inflammation of the conjunctiva and meibomian glands, i.e., blepharoconjunctivitis. Changes like pupil dilation (mydriasis) are not typical effects of isotretinoin; the drug’s eye-related issues are mainly surface and lid problems, not changes in pupil size. There are rare reports of intracranial hypertension (pseudotumor cerebri) with retinoids, but this is uncommon and not part of the usual ocular side-effect profile. So the feature that does not fit isotretinoin’s typical eye effects is mydriasis.