Which of the following is a main side effect of Rifampin?

• A. Blue sclera
• B. Nephrotoxicity
• C. Hepatotoxicity
• D. Pink tears

Answer: (C)

Rifampin is known for causing liver injury, so hepatotoxicity is the primary adverse effect to watch for. This means the drug can raise liver enzymes and even lead to hepatitis in some patients. Because of this risk, liver function tests are often monitored before and during treatment, and symptoms like jaundice, dark urine, pale stools, right upper quadrant pain, or unusual fatigue should prompt evaluation and possible dose adjustment or discontinuation.

In addition to hepatotoxicity, rifampin does discolor bodily fluids—tears, urine, sweat—an orange-red color. This is a benign but noticeable effect and can alarm patients if they’re not warned about it. Other listed effects, like blue sclera or nephrotoxicity, aren’t characteristic main adverse effects of rifampin, while the fluid discoloration is common but not harmful.