Which of the following is NOT one of the major topical uses for fluoroquinolones?

• A. Bacterial conjunctivitis
• B. Ocular Toxoplasmosis
• C. Contact lens related corneal ulcers
• D. Corneal abrasions

Answer: (B)

The main idea is that topical fluoroquinolones are chosen for bacterial infections of the eye because they effectively kill bacteria and penetrate ocular tissues well. They are routinely used for bacterial conjunctivitis, and they are also used for keratitis such as contact lens–related corneal ulcers and for corneal abrasions where there’s a risk of bacterial infection.

Ocular toxoplasmosis, on the other hand, is caused by the parasite Toxoplasma gondii. It does not respond to antibiotics that target bacterial DNA gyrase and topoisomerase IV, and its treatment requires antiparasitic therapy (often systemically, with agents like pyrimethamine-sulfadiazine or alternatives). Therefore, it is not considered a major topical use for fluoroquinolones.

So the item that does not fit as a major topical use is ocular toxoplasmosis.