Which of the following is a first-generation H1 blocker?

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Multiple Choice

Which of the following is a first-generation H1 blocker?

Explanation:
First-generation H1 antagonists are known for their ability to cross the blood–brain barrier and cause central nervous system effects like sedation, along with anticholinergic side effects. Promethazine fits this profile: it is a classic H1 blocker with strong sedative and antiemetic properties because it readily enters the CNS and has anticholinergic actions. The other listed drugs are second-generation antihistamines designed to minimize CNS penetration, so they are much less sedating and have fewer anticholinergic effects. Thus, Promethazine is the first-generation H1 blocker.

First-generation H1 antagonists are known for their ability to cross the blood–brain barrier and cause central nervous system effects like sedation, along with anticholinergic side effects. Promethazine fits this profile: it is a classic H1 blocker with strong sedative and antiemetic properties because it readily enters the CNS and has anticholinergic actions. The other listed drugs are second-generation antihistamines designed to minimize CNS penetration, so they are much less sedating and have fewer anticholinergic effects. Thus, Promethazine is the first-generation H1 blocker.

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