Which of the following is NOT a well known ocular side effect of TCAs such as amitriptyline?

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Multiple Choice

Which of the following is NOT a well known ocular side effect of TCAs such as amitriptyline?

Explanation:
TCAs have strong anticholinergic effects in the eye. Blocking muscarinic receptors causes the pupil to dilate (mydriasis) and reduces tear production, leading to dry eye. The dilation can also narrow the anterior chamber angle in susceptible eyes, increasing the risk of angle-closure glaucoma. They do not decrease intraocular pressure; in fact, they can worsen or precipitate angle-closure in some patients. So the option that describes decreased intraocular pressure is not a known ocular side effect.

TCAs have strong anticholinergic effects in the eye. Blocking muscarinic receptors causes the pupil to dilate (mydriasis) and reduces tear production, leading to dry eye. The dilation can also narrow the anterior chamber angle in susceptible eyes, increasing the risk of angle-closure glaucoma. They do not decrease intraocular pressure; in fact, they can worsen or precipitate angle-closure in some patients. So the option that describes decreased intraocular pressure is not a known ocular side effect.

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