Which of the following is NOT a side effect associated with Aspirin use?

• A. Bleeding complications in the eye
• B. IOP spike
• C. Gastric ulcers
• D. Reye's syndrome in kids

Answer: (B)

Aspirin’s adverse effect profile is dominated by effects on the GI tract and bleeding risk, not on eye pressure. Inhibiting COX reduces protective prostaglandins in the gastric mucosa, which explains common side effects like gastric ulcers. It also increases bleeding tendency, which is why it’s avoided in children with viral infections due to the risk of Reye’s syndrome. An increase in intraocular pressure is not a known or expected side effect of aspirin, since IOP is governed by mechanisms in the eye related to aqueous humor dynamics and is more commonly affected by glaucoma medications, steroid use, or eye injury. Ocular bleeding can occur with antiplatelet therapy in certain contexts, but it isn’t a characteristic, standalone adverse effect of aspirin. Therefore, the statement about an intraocular pressure spike is not associated with aspirin use.