Which of the following is an example of a Sulfonylurea?

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Multiple Choice

Which of the following is an example of a Sulfonylurea?

Explanation:
Sulfonylureas increase insulin secretion from pancreatic beta cells by closing the ATP-sensitive potassium channel, which depolarizes the cell and triggers calcium influx to release insulin. Glipizide is a sulfonylurea, fitting this mechanism. The other drugs belong to different classes: metformin is a biguanide that lowers hepatic glucose production; pioglitazone is a thiazolidinedione that improves insulin sensitivity via PPAR-γ; acarbose is an alpha-glucosidase inhibitor that slows carbohydrate absorption.

Sulfonylureas increase insulin secretion from pancreatic beta cells by closing the ATP-sensitive potassium channel, which depolarizes the cell and triggers calcium influx to release insulin. Glipizide is a sulfonylurea, fitting this mechanism. The other drugs belong to different classes: metformin is a biguanide that lowers hepatic glucose production; pioglitazone is a thiazolidinedione that improves insulin sensitivity via PPAR-γ; acarbose is an alpha-glucosidase inhibitor that slows carbohydrate absorption.

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