Which of the following medications is NOT known to cause Oculogyric crisis?

• A. Aspirin
• B. Zyrtec
• C. Chlorpromazine
• D. Thioridazine

Answer: (A)

Oculogyric crisis is a type of acute dystonia caused by blocking dopamine D2 receptors in the nigrostriatal pathway. It is a motor-side effect most strongly associated with typical antipsychotics that have strong dopamine-blocking effects, such as chlorpromazine and thioridazine, which can provoke sustained eye and neck postures. Aspirin, on the other hand, is an NSAID with no dopamine-receptor antagonism and no impact on the extrapyramidal motor system, so it is not known to cause this reaction. Zyrtec is not a typical cause either, but the classic drugs linked to oculogyric crisis are the dopamine-blocking antipsychotics, making aspirin the item that does not cause it.