Which of the following Non-opiate analgesics is considered a muscle relaxer and is known to have anti cholinergic side effects?

• A. Acetaminophen
• B. Cyclobenzaprine
• C. Tramadol
• D. Methocarbamol

Answer: (B)

Muscle relaxants chosen for acute musculoskeletal pain often bring anticholinergic effects because they act on central nervous system pathways that influence autonomic function. Cyclobenzaprine works centrally to reduce muscle spasm and its structure is related to tricyclic antidepressants, which explains its anticholinergic side effects—dry mouth, constipation, blurred vision, urinary retention, and potential confusion or drowsiness. Acetaminophen has no muscle-relaxing action, so it doesn’t produce these anticholinergic effects. Tramadol is an opioid-like analgesic with a different mechanism and isn’t classified as a non-opioid muscle relaxant. Methocarbamol is a muscle relaxant but isn’t typically noted for strong anticholinergic effects. Therefore, cyclobenzaprine is the non-opioid analgesic that is considered a muscle relaxer with anticholinergic side effects.